Tvardi Therapeutics Stock Plummets 85% After Disappointing Clinical Trial Results
Tvardi Therapeutics (TVRD) shares collapsed 86.61% in pre-market trading following failed Phase 2 REVERT trial data for its IPF treatment TTI-101. The clinical-stage biopharma found no statistically significant improvement over placebo in treating idiopathic pulmonary fibrosis—a fatal lung scarring disease.
CEO Imran Alibhai emphasized continued data evaluation while redirecting attention to pipeline assets. The company maintains its 2026 timeline for reporting on STAT3 inhibitor TTI-109 and a hepatocellular carcinoma study. This biotech setback contrasts sharply with the 126.58% YTD gain erased by today's collapse.